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Table 3 Ki-values for inhibition of phosphodiesterase-3 (PDE3), phosphodiesterase-5 (PDE5), and inhibition of cAMP- and cGMP-efflux at temperatures ranging from 37 to 20 °C

From: Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

Temperature

PDE3

PDE5

cAMP-efflux

cGMP-efflux

37 °C

0.723 ± 0.195

1.95 ± 0.067

0.805 ± 0.343

0.300 ± 0.191

34 °C

0.651 ± 0.069

2.71 ± 0.487

2.03 ± 1.46

0.505 ± 0.226

32 °C

1.22 ± 0.215

3.94 ± 0.191

1.16 ± 0.526

0.409 ± 0.116

28 °C

1.02 ± 0.291

6.17 ± 1.42

0.918 ± 0.465

0.481 ± 0.159

24 °C

1.34 ± 0.216

6.40 ± 1.67

–

0.320 ± 0.183

20 °C

1.42 ± 0.434

10.0 ± 2.78*

–

0.602 ± 0.174

  1. Values are mean ± SEM and given in µM. * Significant difference (p-value < 0.05), when compared to normothermic baseline. No inhibition of ABCC4-activity was detectable below 28 °C
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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

ISSN: 1757-7241