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Table 1 Kinetics of fibrin clot formation and density after PDMP application

From: Plasmatic and cell-based enhancement by microparticles originated from platelets and endothelial cells under simulated in vitro conditions of a dilutional coagulopathy

Parameters PDMP
WB HD LT
C 1 k C 1 k 10 k 15 k C 1 k 10 k 15 k
Tlag [min] 0,8 (0,2) 1* (0,2) 0,7 (0,1) 0,8 (0,3) 0,8 (0,2) 0,9* (0,1) 0,9 (0,1) 0,9 (0,2) 0,9 (0,1) 0,9 (0,1)
V [μm/min] 25,5 (5,2) 30,8* (3,5) 28,5 (5,7) 30,5 (3,5) 38** (5,1) 39,8*** (3,2) 44,4+++ (6,2) 46 (11,4) 49,3* (16,2) 54,25** (11,37)
Vi [μm/min] 54,2 (8,7) 59,4* (9) 55,7 (9,6) 61,8 (5,7) 71,6*** (2,6) 69** (3,8) 69,5++ (4,1) 70,4 (6,1) 70,9 (5) 71,6 (6,2)
D [a.u] 19.209 (5.878) 21.637* (6.089) 16.570 (4.876) 17.284 (6.098) 16.611* (5.469) 17.097* (6.864) 14.797+++ (4.586) 14.690 (2.951) 14.567 (3.625) 15.488 (3.447)
  1. The following kinetic parameters were determined: Tlag: initial growth rate, V: average clot growth rate and Vi: initial clot growth rate. Clot density was measured as dynamic parameter. Values are presented as median with the corresponding IQR. Statistical significances were marked with plus symbols for differences between unstimulated groups (WB vs. HD and WB vs. LT) or with asterisks for concentration-dependent differences within one experimental group (*,+p ≤ 0.05, **,++p ≤ 0.01, ***,+++p ≤ 0.001), respectively. The abbreviation k signifies a thousand