The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Table 1 Baseline characteristics

	SHAM group (n = 8)	SA group (n = 8)	Sildenafil group (n = 8)	Sildenafil + L-NANE group (n = 8)
Weight (kg)	29.13 ± 2.16	30.63 ± 0.92	30.38 ± 0.92	30.44 ± 0.89
HR	99.00 ± 7.44	101.38 ± 8.30	100.50 ± 10.04	101.52 ± 9.84
MAP, mmHg	103.12 ± 5.19	101.88 ± 5.22	99.00 ± 5.81	102.41 ± 5.21
MPAP, mmHg	23.42 ± 4.32	24.13 ± 5.24	24.34 ± 4.56	23.72 ± 4.68
CO, L/min	2.86 ± 0.22	2.99 ± 0.20	2.99 ± 0.19	2.89 ± 0.22
DO₂, ml/min	444 ± 39	445 ± 34	450 ± 28	439 ± 31
VO₂, ml/min	112 ± 12	112 ± 9	115 ± 12	113 ± 10
ERO₂, %	24.17 ± 2.34	25.44 ± 2.70	25.46 ± 1.49	25.36 ± 1.76
Lac, mmol/L	1.21 ± 0.49	1.31 ± 0.72	1.23 ± 0.401	1.24 ± 0.42

Values are mean ± SD or number (n)
SHAM sham, SA saline, HR heart rate, CO cardiac output; MAP mean aortic pressure, MPAP mean pulmonary arterial pressure, DO₂ oxygen delivery, VO₂ oxygen consumption, ERO₂ extraction of oxygen, Lac lactate

ISSN: 1757-7241