Table 3 Subgroup analysis results for the primary outcome considering variability in outcome assessment and age
Study | Repeated CT scan | Follow-up | Age ≥ 60 yo | Age < 60 yo |
|---|---|---|---|---|
ANTONI_2019 | 1.85% (0.23–6.53%) | NA | NA | 1.85% (0.23–6.53%) |
BATTLE_2017 | 2.27% (0.06–12.02%) | NA | 2.27% (0.06–12.02%) | NA |
CHENOWETH_2018 | NA | 0.00% (0.00–1.92%) | NA | 0.00% (0.00–1.92%) |
ERNSTBRUNNER_2016 | 1.05% (0.29–2.66%) | NA | 1.05% (0.29–2.66%) | NA |
GALLIAZZO_2019 | 1.53% (0.19–5.41%) | NA | NA | 1.53% (0.19–5.41%) |
GANETSKY_2017 | NA | 0.16% (0.00–0.87%) | NA | 0.16% (0.00–0.87%) |
HILL_2018 | 3.29% (1.33–6.65%) | NA | NA | 3.29% (1.33–6.65%) |
HUANG_2019 | 2.52% (0.52–7.19%) | NA | NA | 2.52% (0.52–7.19%) |
MANN_2018 | 0.00% (0.00–3.18%) | NA | 0.00% (0.00–3.18%) | NA |
NISHIJIMA_2012 | NA | 0.00% (0.00–1.53%) | NA | 0.00% (0.00–1.53%) |
PECK_2011 | NA | 0.00% (0.00–3.52%) | NA | 0.0% (0.00–3.52%) |
SCANTLING_2017 | 1.21% (0.15–4.28%) | NA | 1.21% (0.15–4.31%) | NA |
STANITSAS_2016 | 0.00% (0.00–8.81%) | NA | NA | 0.05 (0.00–8.81%) |
SWAP_2016 | NA | 2.31% (0.85–4.95%) | NA | 2.31% (0.85–4.95%) |
TAUBER_2009 | 4.00% (1.10–9.93%) | NA | 4.0% (1.10–9.93%) | NA |
TAYLOR_2012 | 0.00% (0.00–4.25%) | NA | NA | 0.00% (0.00–4.25%) |
No. studies | 11 | 5 | 5 | 11 |
DB mean estimated risk | 1.29% (0.66–2.18%) | 0.22% (0.00–1.05%) | 1.09% (0.18–2.52%) | 0.64% (0.07–1.57%) |
p value for heterogeneity | p = 0.2011 | p = 0.0207 | p = 0.1491 | p = 0.0008 |
I2 statistic | 26% | 66% | 41% | 67% |