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Table 1 Main characteristics of the original studies included in the meta-analysis

From: Incidence of delayed bleeding in patients on antiplatelet therapy after mild traumatic brain injury: a systematic review and meta-analysis

Study Study design Primary outcome of the study Head trauma dynamic Patients enrolled in the original study (No.) Patients enrolled in this meta-analysis (No.) Reference standard for delayed bleeding
ANTONI_2019 Retrospective Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents Blunt head trauma 793 108 RHCT after at least 24 h
BATTLE_2017 Retrospective Incidence of delayed ICH in elderly trauma patients on antithrombotic agents Blunt head trauma 110 44 RHCT at 6 h
CHENOWETH_2018 Prospective Incidence of delayed ICH after head injury Blunt head trauma 859 190 Telephone FU and EMR review
ERNSTBRUNNER_2016 Retrospective S100B prediction for delayed ICH after MTBI in patients on LDA MTBI (GCS > 13) 384 382 RHCT within 48 h
GALLIAZZO_2019 Retrospective Incidence of ICH after MTBI in patients on antithrombotic agents MTBI (GCS ≥ 13) 1846 131 RHCT at 24 h
GANETSKY_2017 Prospective Incidence of ICH after minor falls in patients on antithrombotic agents Head trauma after ground level fall 939 637 Informatic FU and EMR review at 30 days
HILL_2018 Retrospective Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents Blunt head trauma 338 213 RHCT within 48 h
HUANG_2019 Retrospective Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents Blunt head trauma 349 119 RHCT at 4–6 h
MANN_2018 Retrospective Incidence of delayed ICH after a minor fall in elderly patients on antithrombotic agents Head trauma after minor fall 218 114 RHCT before discharge
NISHIJIMA_2012 Prospective Incidence of immediate and delayed ICH after blunt head trauma in patients on warfarin or clopidogrel MTBI (GCS ≥ 13) 1064 239 Telephone FU and EMR review at 14 days
PECK_2011 Retrospective Incidence of delayed ICH after blunt head trauma in patients on prescription antithrombotic agents Blunt head trauma 500 103 EMR and informatic FU
SCANTLING_2017 Retrospective Incidence of delayed ICH after MTBI in patients on antithrombotic agents MTBI (GCS > 13) 234 165 RHCT at 12 h
STANITSAS_2016 Retrospective Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents Blunt head trauma 71 40 RHCT
SWAP_2016 Retrospective Incidence of delayed ICH after blunt head trauma in patients on warfarin or clopidogrel Blunt head trauma 491 260 FU from medical records at 60 days
TAUBER_2009 Prospective Incidence of delayed ICH after MTBI in elderly patients on LDA MTBI (GCS 15) 100 100 RHCT at 12–24 h
TAYLOR_2012 Retrospective Incidence of delayed ICH after blunt head trauma in patients on antithrombotic agents Blunt head trauma 159 85 RHCT within 48 h
  1. GCS = Glasgow Coma Scale; MTBI = mild traumatic brain injury; LDA = low-dose acetylsalicylic acid; ICH = intracranial hemorrhage; RHCT = routine repeated head computed tomography scan; FU = follow-up; EMR = electronic medical record
  2. *Only abstract available