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Table 2 Sampling time and biomarker concentrations in prehospital and in-hospital blood samples from mild TBI patients

From: Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild traumatic brain injury: a prospective observational multicenter cohort study – “the PreTBI I study”

  Prehospital serum samples In-hospital serum samples P-value
Time from trauma to sampling min., median (IQR) 45 (27;84) 108 (85;149) < 0.001*
S100B μg/L, mean (95%CI) 0.29 (0.26;0.32) 0.17 (0.16;0.18) < 0.001**
S100B ≥0.10 μg/L, n/N (%) 484/566 (85.5) 398/566 (70.0)
S100B < 0.10 μg/L, n/N (%) 82/566 (14.5) 168/566 (30.0)
Lowest S100B concentration in patient with intracranial lesion, μg/L 0.13 0.10
GFAP ng/mL, range 0.50–1.78 0.50–2.34
GFAP, ≥0.045 ng/mL, n/N (%) 6/566 (1.0) 9/566 (1.6)
GFAP, < 0.045 ng/mL, n/N (%) 560/566 (99.0) 557/566 (98.4)
Hemolysis Index, mean (95%CI) 0.21 (0.20;0.23) 0.054 (0.050;0.058) < 0.001**
  1. * Continuous, two sample mean, paired, non-parametric Wilcoxon Signed rank test
  2. ** Continuous, two sample mean, paired, parametric testing of log-variable