Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry

Table 1 Reference ranges for standard TEM parameters CT, A10, MCF. Reference ranges are presented for plasma and whole blood. Plasma ranges are derived from an internal control group. Values from an external control group from previous studies are also highlighted for comparison. Whole blood reference ranges are shown for comparison with TEM results of CRF under presence of platelets. The recommended treatment thresholds are presented to provide a clinical context of the obtained TEM results

Reference ranges	Plasma (Internal control)^a	Plasma (External control)^b	Whole blood^c	Treatment threshold^d
*CT (sec***)	47–54	53–71	42–74	> 80
A10 (mm)	17–24	n.a.	43–65	< 7
MCF (mm)	18–26	17–35	49–71	< 14

^a Values derived from fresh plasma from 33 healthy, non-medicated volunteers. Reference range corresponds to 95% confidence interval
^b Values derived from fresh plasma as published by Schörgenhofer et al. [13]
^c Values derived from whole blood as published by Lang et al. [14]
^d Treatment thresholds for whole blood EXTEM-CT and whole blood FIBTEM-A10/MCF as published by
Schöchl and Schlimp [15]. and Ranucci et al. [16]

ISSN: 1757-7241