The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p

Table 2 Cardiopulmonary resuscitation outcomes

	SA group (n = 8)	Sildenafil group (n = 8)	Sildenafil + L-NAME group (n = 8)
Number of defibrillatory shocks	4.31 ± 1.62	2.91 ± 0.83	3.72 ± 0.71
Cumulative defibrillation energy (J)	145.01 ± 33.41	95.02 ± 33.41*^#	115.23 ± 23.14*
Duration of CPR before ROSC (min)	6.12 ± 2.21	4.71 ± 1.32	5.43 ± 1.58
6-h survival	3	7*	6*
24-h survival	1	7*^#	4*

Values are mean ± SD or number (n)
SA saline, ROSC restoration of spontaneous circulation, CPR cardiopulmonary resuscitation
*p < 0.05 vs. SA group, ^#p < 0.05 vs. Sildenafil+L-NAME group

ISSN: 1757-7241