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Table 3 Association of therapeutic hypothermia with survival in CA patients receiving ECPR

From: Associations of therapeutic hypothermia with clinical outcomes in patients receiving ECPR after cardiac arrest: systematic review with meta-analysis

Subgroup

N

OR

LCI

UCI

POR

Model

Phetero

I2

Pbegg

Pegger

Overall

9

2.540

1.245

5.180

0.010

R

0.007

61.70%

0.754

0.703

Control type

 Other temperature controls

5

2.542

1.046

6.174

0.039

R

0.016

67.40%

  

 Non-TH induction

4

2.364

0.564

9.919

0.240

R

0.046

62.50%

  

Regions

 Japan

3

3.478

0.625

19.373

0.155

R

0.002

83.60%

  

 Korea

4

1.953

0.522

7.308

0.320

R

0.043

63.20%

  

Sample size

  < 80

4

2.984

0.328

27.124

0.332

R

0.007

75.50%

  

  ≥ 80

5

2.370

1.230

4.567

0.010

R

0.075

52.90%

  

CA location

 Mixed

4

1.703

1.004

2.889

0.048

F

0.193

36.50%

  

 OHCA

5

3.759

1.001

14.122

0.050

R

0.015

67.60%

  

mNOS score

  ≥ 7

4

3.248

1.909

5.525

< 0.001

F

0.112

49.90%

  

  < 7

5

1.540

0.461

5.141

0.482

R

0.019

66.10%

  

OR obtained methods

 U

8

2.683

1.134

6.347

0.025

R

0.004

66.10%

  

 M

1

         

Follow-up

 Discharge/30 days

8

2.106

1.106

4.008

0.023

R

0.040

52.40%

  

 90 days

1

         
  1. Abbreviations: TH therapeutic hypothermia; CA cardiac arrest; IHCA in of hospital cardiac arrest; OR odds ratios; 95%CI 95% confidence interval; LCI lower 95% confidence interval; UCI upper 95% confidence interval; F fixed-effects model; R random-effects model; Phetero, P-value for heterogeneity; Pbegg, P-value for Begg’s test; Pegger, P-value for Egger’s test; U univariate analysis; M multivariate analysis; mNOS modified Newcastle-Ottawa scale