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Table 1 A modified excerpt of the original ‘Figure S3’ in the supplementary appendix of the CHEST trial[13]

From: Hydroxyethyl starch - the importance of being earnest

RIFLE category and component

HES n/N (%)

Saline n/N (%)

Relative risk 95% confidence interval

p

Result

RIFLE-R (risk)

1788/3309 (54.0)

1912/3335 (57.3)

0.94 (0.90-0.98)

0.007

HES better

Creatinine increase (x1,5) from baseline

462/3149 (14.7)

415/3171 (13.1)

1.12 (0.99-1.27)

0.07

n.s.

Urine output <0.5 ml/kg/h x 6 h

1701/3230 (52.7)

1846/3266 (56.5)

0.93 (0.89-0.97)

0.002

HES better

RIFLE-I (injury)

1130/3265 (34.6)

1253/3300 (38.0)

0.91 (0.85-0.97)

0.005

HES better

Creatinine increase (x2) from baseline

245/3149 (7.8)

191/3171 (6.0)

1.29 (1.08-1.55)

0.006

Saline better

Urine output <0.5 ml/kg/h x 12 h

1077/2977 (36.2)

1200/3024 (39.7)

0.91 (0.85-0.97)

0.005

HES better

  1. The results clearly contradict the statement in the original manuscript that in subgroup analyses “post-hoc tests show a higher relative risk of meeting the criteria for the risk of kidney dysfunction (RIFLE-R) or kidney injury (RIFLE-I) in the HES group than in the saline group”.