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Table 4 Univariate and multivariate Cox proportional-hazards models for a composite of both periods and within each period (2001-3, 2005-7).

From: Blood product ratio in acute traumatic coagulopathy - effect on mortality in a Scandinavian level 1 trauma centre

   Univariate Multivariate
   HR (95% CI)1 P-value HR (95% CI)1 P-value
Study period 2001-3 and 2005-7 (n = 220) 7
ISS score2 1.03 (1.01-1.06) 0.001 1.03 (1.01-1.06) 0.007
Age years3 1.04 (1.02-1.05) < 0.001 1.04 (1.03-1.06) < 0.001
RBC 0-6 h n4 1.03 (1.01-1.05) 0.013 1.01 (0.96-1.05) 0.756
FFP 0-6 h n4 1.02 (1.00-1.05) 0.055 0.94 (0.84-1.06) 0.329
PLT 0-6 h n4 1.06 (1.01-1.11) 0.014 1.12 (0.92-1.36) 0.246
Platelet count 10*109/l5 0.96 (0.93-0.99) 0.007 0.99 (0.96-1.02) 0.353
APTT > 35 s6 4.60 (2.69-7.88) < 0.001 3.09 (1.61-5.93) < 0.001
Study period 2001-3 (n = 79) 7
ISS score2 1.01 (0.97-1.05) 0.646 1.02 (0.98-1.07) 0.350
Age years3 1.05 (1.02-1.07) < 0.001 1.05 (1.03-1.08) < 0.001
RBC 0-6 h n4 1.01 (0.95-1.07) 0.817 0.97 (0.88-1.07) 0.520
FFP 0-6 h n4 0.94 (0.80-1.11) 0.474 0.70 (0.49-0.99) 0.045
PLT 0-6 h n4 1.20 (0.63-2.26) 0.582 5.30 (0.79-35.32) 0.085
Platelet count 10*109/l5 0.97 (0.92-1.03) 0.371 0.97 (0.91-1.02) 0.247
APTT > 35 s6 3.42 (1.28-9.15) 0.014 2.47 (0.66-9.21) 0.177
Study period 2005-7 (n = 141) 7
ISS score2 1.04 (1.02-1.07) 0.001 1.04 (1.01-1.07) 0.020
Age years3 1.03 (1.01-1.05) < 0.001 1.04 (1.02-1.06) < 0.001
RBC 0-6 h n4 1.03 (1.01-1.05) 0.016 1.04 (0.97-1.12) 0.223
FFP 0-6 h n4 1.02 (1.00-1.05) 0.085 0.98 (0.87-1.11) 0.749
PLT 0-6 h n4 1.05 (1.00-1.10) 0.061 0.95 (0.76-1.19) 0.676
Platelet count 10*109/l5 0.95 (0.92-0.99) 0.011 0.98 (0.95-1.02) 0.320
APTT > 35 s6 5.04 (2.62-9.68) < 0.001 3.41 (1.55-7.51) 0.002
  1. 1Relative hazards with 95% confidence intervals (HR (95% CI)) and p-values are shown for all variables, with p-values in bold for variables with p < 0.05. 2One unit increase in ISS, 3One years older, 4One more unit of the respective blood component, 5A 10*109/l increase in platelet count, 6APTT > 0.35 s (above reference range). 7Each univariate and multivariate Cox models only included patients with complete data (i.e., the same patients were included in each univariate and multivariate analyses)