Table 1 Summary of Important Trials Published*
From: The contemporary role of blood products and components used in trauma resuscitation
Author and Year | Patient Group | rFVIIa Dosing | Primary Endpoint | Outcomes |
|---|---|---|---|---|
Boffard; [67] J Trauma 2005; 59:8-18 | Penetrating and blunt trauma (301) | 200+100+100 μg/kg | RBC units first 24 hours | Reduction in RBCs (blunt) |
Raobaikady; [68] Br J Anaesth 2005; 94:586-591 | Pelvic fractures (48) | 90 μg/kg | Perioperative blood loss | No difference |
Hauser; [69] J Trauma 2010; 69:489-500 | Blunt and penetrating trauma (573) | 200+100+100 μg/kg | Mortality, blood product use | No mortality difference, Less product use |
Wade; [70] J Trauma 2010; 69:353-359** | Military trauma (2,050) | Varied | Complications, mortality | No difference |